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Dynamic states of ErbB1 phosphorylation predicted by spatial-stochastic modeling
Receptor shuffle mechanism and state analysis
![Receptor shuffle mechanism and state analysis](/system/content_item_assets/images/2049/large/0549500_2013_Figure_3.jpg)
(A) Receptor shuffle mechanism. Two receptors dimerize, causing an asymmetric tail configuration leading to one tail being activated and phosphorylating the other tail. The dimer must then fall apart and re-dimerize in order to have both tails phosphorylated. (B) Receptor state transitions over a 4 minute simulation for a single ligand bound receptor (Top) and the average state through out a 4 minute simulation, of all ligand bound receptors (Bottom). © Receptor state transitions over a 4 minute simulation for a single unliganded receptor (Top) and the average state through out a 4 minute simulation, of unliganded receptors (Bottom).
Credits: Meghan M. McCabe, University of New Mexico