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Investigating controlled drug release

Research Achievements

Investigating controlled drug release

Chris Huth (Materials Science) working with his IGERT advisor, Donglu Shi, and an interdisciplinary team consisting of Giovanni Pauletti (College of Pharmacy) and Dong Qian (Mechanical Engineering) at the University of Cincinnati, have been investigating the use of magnetic hyperthermia as a means of controlled drug release for cancer applications. During this reporting period Chris has perfected a method of coating a phospholipids bilayer onto iron oxide nanoparticles and storing a lipophilic molecule within this coating. He was able to show that upon heating and reaching the melting temperature of the coating, a lipophilic fluorescent dye (mimicking a drug) is released out of the coating.