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Novel Silica Nanoparticles Enhance Gene Delivery to the Spinal Cord: Potential to Control Pathological Pain
Behavioral responses to light mechanical touch stimuli applied to the hindpaws remains near baseline levels following intrathecal injection of protocells.
![Behavioral responses to light mechanical touch stimuli applied to the hindpaws remains near baseline levels following intrathecal injection of protocells.](/system/content_item_assets/images/816/large/0549500_2010_Dose-response_curve_r_and_l.jpg)
Graphs represent animal withdrawal responses from left (A, C) and right (B, D) hind paw responses following treatment with protocells supporting a DOTAP: CHOL 1:1 (A, B) or DOPC (C, D) lipid bilayer. The Y-axis (right) is the stimulus intensity in grams and the Y-axis (left) is the log stimulus intensity (mg x 10). The X- axis depicts time at baseline (BL) before injection and hours post injection of protocells (1mg).
Credits: Ellen Dengler, University of New Mexico